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Need for manual segmentation in optical coherence tomography angiography of neovascular age-related macular degeneration
- Source :
- PLoS ONE, Vol 15, Iss 12, p e0244828 (2020), PLOS ONE, 15(12):e0244828. Public Library of Science, PLoS ONE, 15(12):e0244828. Public Library of Science, PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Purpose To compare the characteristics of eyes that had manual vs. automated segmentation of choroidal neovascular membrane (CNVM) using optical coherence tomography angiography (OCTA). Methods All patients with CNVM underwent OCTA using the Zeiss Angioplex Cirrus 5000. Slabs of the avascular outer retina, outer retina to choriocapillaris (ORCC) region and choriocapillaris were generated. Manual segmentation was done when there were significant segmentation artifacts. Presence of activity of CNVM was adjudged by the presence of subretinal fluid (SRF) on structural OCT and was compared to activity detected on en face OCTA slabs based on well-defined criteria. Results Eighty-one eyes of 81 patients were recruited of which manual segmentation was required in 46 (57%). Eyes with automated segmentation had significantly more CNVM in the ORCC (75%) whereas those with manual segmentation had deeper CNVM (sub-RPE = 22%, intra-PED = 22%) (p Conclusions Manual segmentation of OCTA is required in more than 50% eyes with CNVM and this progressively increases with increasing depth of CNVM location from the ORCC to below the RPE. There is moderate concordance between OCTA and structural OCT in determining CNVM activity.
- Subjects :
- genetic structures
Vision
Image Processing
Social Sciences
Cardiovascular Medicine
Fluorescein Angiography/methods
Tomography, Optical Coherence/methods
Diagnostic Radiology
Macular Degeneration
ARTIFACTS
Medicine and Health Sciences
Psychology
Medicine
Cardiovascular Imaging
Fluorescein Angiography
Tomography
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Angiography
Software Engineering
medicine.anatomical_structure
Engineering and Technology
Sensory Perception
Manual segmentation
Anatomy
Tomography, Optical Coherence
Research Article
Computer and Information Sciences
medicine.medical_specialty
Imaging Techniques
Ocular Anatomy
Science
Optical Coherence/methods
BIOMARKERS
Cardiology
Automated segmentation
Image Analysis
Research and Analysis Methods
Retina
Computer Software
Macular Degeneration/diagnostic imaging
Ocular System
Diagnostic Medicine
Ophthalmology
Age related
Choroidal neovascular membrane
Humans
business.industry
Cognitive Psychology
Biology and Life Sciences
Optical coherence tomography angiography
Macular degeneration
medicine.disease
eye diseases
Cross-Sectional Studies
Signal Processing
Eyes
Cognitive Science
Perception
sense organs
business
Head
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....6f1c5b7ffc279cbb8743901c11df10d4