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Paper-Based Biosensors for COVID-19: A Review of Innovative Tools for Controlling the Pandemic
- Source :
- ACS Omega, Vol 6, Iss 44, Pp 29268-29290 (2021), ACS Omega, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2021
- Publisher :
- American Chemical Society, 2021.
-
Abstract
- The appearance and quick spread of the new severe acute respiratory syndrome coronavirus disease, COVID-19, brought major societal challenges. Importantly, suitable medical diagnosis procedures and smooth clinical management of the disease are an emergent need, which must be anchored on novel diagnostic methods and devices. Novel molecular diagnostic tools relying on nucleic acid amplification testing have emerged globally and are the current gold standard in COVID-19 diagnosis. However, the need for widespread testing methodologies for fast, effective testing in multiple epidemiological scenarios remains a crucial step in the fight against the COVID-19 pandemic. Biosensors have previously shown the potential for cost-effective and accessible diagnostics, finding applications in settings where conventional, laboratorial techniques may not be readily employed. Paper- and cellulose-based biosensors can be particularly relevant in pandemic times, for the renewability, possibility of mass production with sustainable methodologies, and safe environmental disposal. In this review, paper-based devices and platforms targeting SARS-CoV-2 are showcased and discussed, as a means to achieve quick and low-cost PoC diagnosis, including detection methodologies for viral genomic material, viral antigen detection, and serological antibody testing. Devices targeting inflammatory markers relevant for COVID-19 are also discussed, as fast, reliable bedside diagnostic tools for patient treatment and follow-up.<br />The authors acknowledge funding through projects Eco2Covid (POCI-01-02B7-FEDER-068174) and TecniCov (POCI-01-02B7-FEDER-069745), co-funded by FEDER through COMPETE2020 and Lisboa2020. T.P., A.R.C. and A.C.M. acknowledge funding to National Foundation for Science and Technology, I.P., FCT, through their PhD grants, references DFA/BD/8606/2020, SFRH/BD/130107/2017 and SFRH/BD/115173/2016, respectively<br />info:eu-repo/semantics/publishedVersion
- Subjects :
- Diagnostic methods
Coronavirus disease 2019 (COVID-19)
Computer science
General Chemical Engineering
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Immunology
02 engineering and technology
Viral antigen
Peptides and proteins
Diagnostic tools
01 natural sciences
Biopolymers
Pandemic
Medical diagnosis
Antigens
QD1-999
Science & Technology
SARS-CoV-2
010401 analytical chemistry
General Chemistry
Paper based
021001 nanoscience & nanotechnology
0104 chemical sciences
3. Good health
Chemistry
Risk analysis (engineering)
Perspective
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 24701343
- Volume :
- 6
- Issue :
- 44
- Database :
- OpenAIRE
- Journal :
- ACS Omega
- Accession number :
- edsair.doi.dedup.....6f159e84988cdbfaf1e0f90415b5e445