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Prospect of circular RNA in osteogenesis: A novel orchestrator of signaling pathways
- Source :
- Journal of cellular physiology. 234(12)
- Publication Year :
- 2019
-
Abstract
- Circular RNAs (circRNAs) were initially regarded as by-products of aberrant splicing. But now, there are substantial evidence on their various roles in the regulation of genes during the development of organs and diseases. Consistent with these breakthroughs, it is experiencing rapid growth that circRNAs function as the important checkpoints during the osteogenesis. Therefore, characterizing the roles of circRNAs is useful and critical to better understanding the process of osteogenic differentiation, which could provide new avenues for the diagnosis and treatment of bone diseases, such as bone defects and osteoporosis. In this review, we presented a map of the interaction between circRNAs and the molecules of signaling pathways associated with osteogenesis, summarized the current knowledge of the biological functions of circRNAs during the osteogenic differentiation, figured out the limits of existing research works, and provided a novel look on the diagnostic and therapeutic methods of bone diseases based on circRNAs.
- Subjects :
- 0301 basic medicine
Physiology
Clinical Biochemistry
Cell Differentiation
Cell Biology
Computational biology
RNA, Circular
Biology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Circular RNA
Osteogenesis
030220 oncology & carcinogenesis
microRNA
Animals
Humans
Aberrant splicing
Signal transduction
Bone Diseases
Function (biology)
Signal Transduction
Subjects
Details
- ISSN :
- 10974652
- Volume :
- 234
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of cellular physiology
- Accession number :
- edsair.doi.dedup.....6f0b27a007b9c02c5406c33268cc177d