Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion

AIM: To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion (BRVO) and macular edema. METHODS: A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography (OCT) imaging and ultra wide-field fluorescein angiography (UWFA). Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion. RESULTS: Intravitreal injections improved best corrected visual acuity (BCVA) significantly from 22.23 +/- 16.33 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters to 36.23 +/- 15.19 letters (P