Two new phenylpropanoids from Swertia atroviolacea and their anti-5α-reductase activity

Two new phenylpropanoids (1–2), together with two known lignans (3–4), were isolated from whole herb of Swertia atroviolacea. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 showed weak activity with reductase inhibitions of 45.6 ± 2.8% and 38.4 ± 2.5%, respectively.