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Detection and Prognostic Significance of Circulating Tumor Cells in Patients With Metastatic Thyroid Cancer
- Source :
- The Journal of clinical endocrinology and metabolism. 101(11)
- Publication Year :
- 2016
-
Abstract
- Context: Individual patient prognostication for advanced thyroid cancer (TC) is challenging. Circulating tumor cells (CTCs) have been shown to be a valuable prognostic marker for other solid cancers. Objective: We hypothesized that CTCs are present in the blood of patients with advanced TC and their number can predict overall survival (OS). Setting: This is a prospective study at a tertiary cancer hospital. Patients, Interventions, and Main Outcome Measures: Initial studies were performed with TC cell lines to determine the feasibility of detection using the Veridex CellSearch. CTC enumeration was performed in blood samples from 18 patients with distantly metastatic medullary TC (metMTC), 14 with distantly metastatic differentiated TC (metDTC), and 10 controls with a history of TC but no evidence of disease. The prognostic value of CTC levels to predict OS in metMTC patients was assessed. Results: CellSearch detected cells from MTC and DTC but not anaplastic TC cell lines. Six metMTC patients but no metDTC or control patients had more than or equal to 5 CTCs detected by the CellSearch assay. Median survival in metMTC patients with more than or equal to 5 CTCs was 13 months vs 51.5 months for those with less than 5 CTCs (P = .0116). The hazard ratio for mortality of patients with more than or equal to 5 CTCs compared with those with less than 5 CTCs was 3.95 (1.20–13.0, P = .0245). Conclusions: The presence of more than or equal to 5 CTCs in patients with metMTC is associated with worse OS. Larger cohorts are required to validate the prognostic value of CTC enumeration.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Pathology
Medullary cavity
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
030209 endocrinology & metabolism
Context (language use)
Disease
Biochemistry
03 medical and health sciences
0302 clinical medicine
Endocrinology
Circulating tumor cell
Internal medicine
Cell Line, Tumor
medicine
Carcinoma
Biomarkers, Tumor
Humans
Prospective Studies
Thyroid Neoplasms
Neoplasm Metastasis
Prospective cohort study
Thyroid cancer
business.industry
Biochemistry (medical)
Cancer
Original Articles
Middle Aged
medicine.disease
Neoplastic Cells, Circulating
Prognosis
Carcinoma, Neuroendocrine
030220 oncology & carcinogenesis
Feasibility Studies
Female
business
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 101
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....6eec6b2a02728b4c32eab8c2c01965bc