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Drug delivery to the posterior segment of the eye for pharmacologic therapy
- Publication Year :
- 2010
-
Abstract
- Treatment of diseases of the posterior segment of the eye, such as age-related macular degeneration, cytomegalovirus retinitis, diabetic retinopathy, posterior uveitis and retinitis pigmentosa, requires novel drug delivery systems that can overcome the many barriers for efficacious delivery of therapeutic drug concentrations. This challenge has prompted the development of biodegradable and nonbiodegradable sustained-release systems for injection or transplantation into the vitreous as well as drug-loaded nanoparticles, microspheres and liposomes. These drug delivery systems utilize topical, systemic, subconjunctival, intravitreal, transscleral and iontophoretic routes of administration. The focus of research has been the development of methods that will increase the efficacy of spatiotemporal drug application, resulting in more successful therapy for patients with posterior segment diseases. This article summarizes recent advances in the research and development of drug delivery methods of the posterior chamber of the eye, with an emphasis on the use of implantable devices as well as micro- and nanoparticles.
- Subjects :
- Drug
medicine.medical_specialty
business.industry
media_common.quotation_subject
Biomedical Engineering
Diabetic retinopathy
Macular degeneration
medicine.disease
Article
Surgery
Posterior segment of eyeball
Transplantation
Ophthalmology
Retinitis pigmentosa
Drug delivery
medicine
Cytomegalovirus retinitis
business
Optometry
media_common
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6ee3b863a64b0522de5f436b8927b26c