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The association between, depression, anxiety, and mortality in older people across eight low‐ and middle‐income countries: Results from the 10/66 cohort study

The association between, depression, anxiety, and mortality in older people across eight low‐ and middle‐income countries: Results from the 10/66 cohort study

Authors :
Ivonne Z. Jimenez-Velazquez
Ana Luisa Sosa
Martin Prince
Mariella Guerra
Carolina Kralj
Yueqin Huang
A. Matthew Prina
Aquiles Salas
Rasha Alkholy
Juan J. Llibre Rodriguez
Daisy Acosta
Zhaorui Liu
Amuthavalli Thiyagarajan Jotheeswaran
Yu-Tzu Wu
Source :
Wu, Y-T, Kralj, C, Acosta, D, Guerra, M, Huang, Y, T Jotheeswaran, A, Z. Jimenez-Velazquez, I, Liu, Z, J Llibre Rodriguez, J, Salas, A, Luisa Sosa, A, Alkholy, R, Prince, M & Prina, A M 2019, ' The association between, depression, anxiety and mortality in older people across eight low-and middle-income countries: results from the 10/66 cohort study ', International Journal of Geriatric Psychiatry. https://doi.org/10.1002/gps.5211, International Journal of Geriatric Psychiatry
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

Objectives Depression and anxiety are common mental disorders in later life. Few population-based studies have investigated their potential impacts on mortality in low- and middle-income countries (LMICs). The aim of this study is to examine the associations between depression, anxiety, their comorbidity, and mortality in later life using a population-based cohort study across eight LMICs. Methods This analysis was based on the 10/66 cohort study including 15 991 people aged 65 years or above in Cuba, Dominican Republic, Venezuela, Mexico, Peru, Puerto Rico, China, and India, with an average follow-up time of 3.9 years. Subthreshold and clinical levels of depression were determined using EURO-D and ICD-10 criteria, and anxiety was based on Geriatric Mental State (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT). Cox proportional hazard modelling was used to estimate how having depression, anxiety, or both was associated with mortality adjusting for sociodemographic and health factors. Results Participants with clinical depression (hazard ratio [HR]: 1.45; 95% CI, 1.24-1.70) and subthreshold anxiety (HR: 1.26; 95% CI, 1.15-1.38) had higher risk of mortality than those without the conditions after adjusting for sociodemographic factors and health conditions. Comorbidity of depression and anxiety was associated with a 30% increased risk of mortality but the effect sizes varied across countries (Higgins I2 = 58.8%), with the strongest association in India (HR: 1.99; 95% CI, 1.21-3.27). Conclusions Depression and anxiety appear to be associated with mortality in older people living in LMICs. Variation in effect sizes may indicate different barriers to health service access across countries. Future studies may investigate underlying mechanisms and identify potential interventions to reduce the impact of common mental disorders.

Details

ISSN :
10991166 and 08856230
Volume :
35
Database :
OpenAIRE
Journal :
International Journal of Geriatric Psychiatry
Accession number :
edsair.doi.dedup.....6ed4936f210bc4cf168b0ffed11eca00
Full Text :
https://doi.org/10.1002/gps.5211