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The association between, depression, anxiety, and mortality in older people across eight low‐ and middle‐income countries: Results from the 10/66 cohort study
The association between, depression, anxiety, and mortality in older people across eight low‐ and middle‐income countries: Results from the 10/66 cohort study
- Source :
- Wu, Y-T, Kralj, C, Acosta, D, Guerra, M, Huang, Y, T Jotheeswaran, A, Z. Jimenez-Velazquez, I, Liu, Z, J Llibre Rodriguez, J, Salas, A, Luisa Sosa, A, Alkholy, R, Prince, M & Prina, A M 2019, ' The association between, depression, anxiety and mortality in older people across eight low-and middle-income countries: results from the 10/66 cohort study ', International Journal of Geriatric Psychiatry. https://doi.org/10.1002/gps.5211, International Journal of Geriatric Psychiatry
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Objectives Depression and anxiety are common mental disorders in later life. Few population-based studies have investigated their potential impacts on mortality in low- and middle-income countries (LMICs). The aim of this study is to examine the associations between depression, anxiety, their comorbidity, and mortality in later life using a population-based cohort study across eight LMICs. Methods This analysis was based on the 10/66 cohort study including 15 991 people aged 65 years or above in Cuba, Dominican Republic, Venezuela, Mexico, Peru, Puerto Rico, China, and India, with an average follow-up time of 3.9 years. Subthreshold and clinical levels of depression were determined using EURO-D and ICD-10 criteria, and anxiety was based on Geriatric Mental State (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT). Cox proportional hazard modelling was used to estimate how having depression, anxiety, or both was associated with mortality adjusting for sociodemographic and health factors. Results Participants with clinical depression (hazard ratio [HR]: 1.45; 95% CI, 1.24-1.70) and subthreshold anxiety (HR: 1.26; 95% CI, 1.15-1.38) had higher risk of mortality than those without the conditions after adjusting for sociodemographic factors and health conditions. Comorbidity of depression and anxiety was associated with a 30% increased risk of mortality but the effect sizes varied across countries (Higgins I2 = 58.8%), with the strongest association in India (HR: 1.99; 95% CI, 1.21-3.27). Conclusions Depression and anxiety appear to be associated with mortality in older people living in LMICs. Variation in effect sizes may indicate different barriers to health service access across countries. Future studies may investigate underlying mechanisms and identify potential interventions to reduce the impact of common mental disorders.
- Subjects :
- Male
Population
Psychological intervention
Anxiety
Cohort Studies
03 medical and health sciences
0302 clinical medicine
medicine
Risk of mortality
Humans
030212 general & internal medicine
education
Developing Countries
Research Articles
Depression (differential diagnoses)
Aged
common mental disorders
Aged, 80 and over
education.field_of_study
Depression
business.industry
Hazard ratio
medicine.disease
mortality
Comorbidity
3. Good health
030227 psychiatry
Psychiatry and Mental health
Female
epidemiology
Geriatrics and Gerontology
medicine.symptom
business
Research Article
Cohort study
Demography
Subjects
Details
- ISSN :
- 10991166 and 08856230
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- International Journal of Geriatric Psychiatry
- Accession number :
- edsair.doi.dedup.....6ed4936f210bc4cf168b0ffed11eca00
- Full Text :
- https://doi.org/10.1002/gps.5211