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Clinical and neuroimaging risk factors for cognitive decline in community‐dwelling older adults living in rural Ecuador. A population‐based prospective cohort study
- Source :
- International Journal of Geriatric Psychiatry. 34:447-452
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- OBJECTIVE There is limited information on factors influencing cognitive decline in rural settings from low- and middle-income countries. Using the Atahualpa Project cohort, we aimed to assess the burden of cognitive decline in older adults living in a rural Ecuadorian village. METHODS The study included Atahualpa residents aged greater than or equal to 60 years who had a follow-up Montreal Cognitive Assessment (MoCA) repeated at least 1 year after baseline. MoCA decline was assessed by multivariable longitudinal linear models, adjusted for demographics, days between MoCA tests, cardiovascular risk factors, and neuroimaging signatures of structural brain damage. RESULTS We included 252 individuals who contributed 923.7 person-years of follow-up (mean: 3.7 ± 0.7 years). The mean baseline MoCA was 19.5 ± 4.5 points, and the follow-up MoCA was 18.1 ± 4.9 points (P = 0.001). Overall, 154 individuals (61%) had lower MoCA scores at follow-up. The best fitted longitudinal linear model showed a decline of follow-up MoCA from baseline (β: 0.14; 95% CI, 0.0-0.21; P
- Subjects :
- Male
Rural Population
Gerontology
Glucose control
Neuroimaging
Population based
Article
03 medical and health sciences
Cognition
0302 clinical medicine
Risk Factors
Humans
Medicine
Cognitive Dysfunction
Prospective Studies
030212 general & internal medicine
Cognitive decline
Prospective cohort study
Aged
Aged, 80 and over
Cerebral Cortex
business.industry
Montreal Cognitive Assessment
Middle Aged
Mental Status and Dementia Tests
Hyperintensity
Psychiatry and Mental health
Cohort
Linear Models
Female
Ecuador
Independent Living
Atrophy
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10991166 and 08856230
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- International Journal of Geriatric Psychiatry
- Accession number :
- edsair.doi.dedup.....6ecf4ae418b4a7ce158c9a210a78a5de