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Imunomodulação relacionada à transfusão de hemocomponentes
- Source :
- Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS
- Publication Year :
- 2014
-
Abstract
- The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.
- Subjects :
- Kidney
Blood transfusion
Imunomodulacao
Transfusão de sangue
business.industry
medicine.medical_treatment
Leucócitos
General Medicine
Boold transfusion
Immunomodulation
medicine.anatomical_structure
Immunity
Immunology
Allograft survival
medicine
Leukocytes
In patient
Immunisuppression
business
Infection
Imunossupressão
Infecção
Subjects
Details
- Language :
- Portuguese
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS
- Accession number :
- edsair.doi.dedup.....6ec93f3b610de0552886a8df1c7ac419