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Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies
- Source :
- Animal biotechnology. 30(4)
- Publication Year :
- 2018
-
Abstract
- The human cluster of differentiation 19 (CD19) is highly expressed in most leukemia, rendering is a promising therapeutic target. In this study, we generated anti-CD19 single-chain variable fragments (scFv) from immunized chickens by phage display technology. After constructing a scFv antibody library with 2.5 × 10
- Subjects :
- 0301 basic medicine
Models, Molecular
Phage display
Molecular model
Antigens, CD19
chemical and pharmacologic phenomena
Bioengineering
Computational biology
Biology
CD19
03 medical and health sciences
immune system diseases
hemic and lymphatic diseases
Cell Line, Tumor
medicine
Single-chain variable fragment
Animals
Humans
Cluster of differentiation
Fragment (computer graphics)
0402 animal and dairy science
hemic and immune systems
04 agricultural and veterinary sciences
Surface Plasmon Resonance
medicine.disease
040201 dairy & animal science
Complementarity Determining Regions
Leukemia
030104 developmental biology
biology.protein
Animal Science and Zoology
Antibody
Cell Surface Display Techniques
Chickens
Biotechnology
Single-Chain Antibodies
Subjects
Details
- ISSN :
- 15322378
- Volume :
- 30
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Animal biotechnology
- Accession number :
- edsair.doi.dedup.....6ec5a83cbc924b6f3fbcc7b17cddb3e8