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Vaccine adjuvants as potential cancer immunotherapeutics
- Source :
- International Immunology
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- New adjuvants for cancer immunotherapy<br />Accumulated evidence obtained from various clinical trials and animal studies suggested that cancer vaccines need better adjuvants than those that are currently licensed, which include the most commonly used alum and incomplete Freund’s adjuvant, because of either a lack of potent anti-tumor immunity or the induction of undesired immunity. Several clinical trials using immunostimulatory adjuvants, particularly agonistic as well as non-agonistic ligands for TLRs, C-type lectin receptors, retinoic acid-inducible gene I-like receptors and stimulator of interferon genes, have revealed their therapeutic potential not only as vaccine adjuvants but also as anti-tumor agents. Recently, combinations of such immunostimulatory or immunomodulatory adjuvants have shown superior efficacy over their singular use, suggesting that seeking optimal combinations of the currently available or well-characterized adjuvants may provide a better chance for the development of novel adjuvants for cancer immunotherapy.
- Subjects :
- CpG ODN
0301 basic medicine
CpG Oligodeoxynucleotide
medicine.medical_treatment
Immunology
β-glucan
Pharmacology
Biology
Cancer Vaccines
Immunomodulation
03 medical and health sciences
0302 clinical medicine
Immune system
Adjuvants, Immunologic
Cancer immunotherapy
Immunity
Neoplasms
TLR
medicine
Animals
Humans
Immunology and Allergy
Lectins, C-Type
combination
Clinical Trials as Topic
Invited Review
Vaccination
General Medicine
Immunotherapy
030104 developmental biology
Oligodeoxyribonucleotides
Stimulator of interferon genes
Alum Compounds
Adjuvant
STING
030215 immunology
Subjects
Details
- ISSN :
- 14602377 and 09538178
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- International Immunology
- Accession number :
- edsair.doi.dedup.....6eaeff955ee15a366c2bff230c6965ed