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Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest
- Source :
- Journal of Pharmacological Sciences, Vol 127, Iss 3, Pp 332-338 (2015)
- Publisher :
- Japanese Pharmacological Society. Production and hosting by Elsevier B.V.
-
Abstract
- s Pine needle oil from crude extract of pine needles has been used as an anti-cancer agent in Traditional Chinese Medicine. The α-pinene is a natural compound isolated from pine needle oil which has been shown anti-cancer activity. In previous study, we found that pine needle oil exhibited significant inhibitory effect on hepatoma carcinoma BEL-7402 cells. In this study, we investigate the inhibition of α-pinene on hepatoma carcinoma BEL-7402 cells in vitro and in vivo and further explore the mechanism. The results show that liver cancer cell growth was inhibited obviously with inhibitory rate of 79.3% in vitro and 69.1% in vivo , Chk1 and Chk2 levels were upregulated, CyclinB, CDC25 and CDK1 levels were downregulated.
- Subjects :
- chemistry.chemical_compound
Tumor Cells, Cultured
Bicyclic Monoterpenes
Pinene
Liver Neoplasms
Cyclin-Dependent Kinases
Up-Regulation
G2 Phase Cell Cycle Checkpoints
α-Pinene
Molecular Medicine
Mechanism
Liver cancer
medicine.medical_specialty
Carcinoma, Hepatocellular
animal structures
Cdc25
Down-Regulation
Mice, Nude
Biology
Cyclin B
Inhibitory postsynaptic potential
In vitro and in vivo
Downregulation and upregulation
Internal medicine
CDC2 Protein Kinase
medicine
Carcinoma
Animals
Humans
Plant Oils
Pharmacology
Cyclin-dependent kinase 1
BEL-7402 cells
Cell growth
lcsh:RM1-950
medicine.disease
Pinus
Molecular biology
Antineoplastic Agents, Phytogenic
Checkpoint Kinase 2
Endocrinology
lcsh:Therapeutics. Pharmacology
chemistry
Checkpoint Kinase 1
biology.protein
Monoterpenes
M Phase Cell Cycle Checkpoints
Protein Kinases
Neoplasm Transplantation
Phytotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....6ea9a25577d9fdeac4fb01bb89b979d0
- Full Text :
- https://doi.org/10.1016/j.jphs.2015.01.008