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Effect of SGLT2 inhibitors in a murine model of urinary tract infection with Candida albicans
Effect of SGLT2 inhibitors in a murine model of urinary tract infection with Candida albicans
- Source :
- Diabetes, obesitymetabolism. 16(7)
- Publication Year :
- 2013
-
Abstract
- Aims Urinary tract infection (UTI) is a common clinical problem in diabetic patients; however, the relationship between UTI and glucosuria remains uncertain. To investigate the relationship, we examined the effect of glucosuria induced by sodium glucose cotransporter 2 (SGLT2) inhibitors on the progression of UTI in mice. Methods From 1 day before transurethral inoculation with Candida albicans, female mice were treated orally once a day with an SGLT2 inhibitor in different treatment regimens: (i) dapagliflozin at 10 mg/kg for 2, 3 or 7 days, (ii) dapagliflozin at 0.1, 1 or 10 mg/kg for 3 days and (iii) dapagliflozin, canagliflozin or tofogliflozin at 10 mg/kg for 3 days. To evaluate the ascending UTI, the kidneys were removed 6 days after the inoculation, and the number of viable C. albicans cells in kidney was measured as colony-forming units (CFU). Results In mice treated with dapagliflozin, the number of C. albicans CFU in kidney increased in accordance with both treatment duration and dose. The number of CFU significantly increased when mice were treated with 10 mg/kg dapagliflozin or canagliflozin but not tofogliflozin. With dapagliflozin and canagliflozin, urine glucose concentration (UGC) significantly increased up to 24 h after drug administration; with tofogliflozin, UGC significantly increased only up to 12 h after drug administration. Conclusions Our data indicate that increased susceptibility to UTI is associated with a persistent increase in UGC.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Urinary system
Thiophenes
Pharmacology
Kidney
chemistry.chemical_compound
Mice
Endocrinology
Glucosides
Glycosuria
Internal medicine
Candida albicans
Internal Medicine
medicine
Animals
Dapagliflozin
Benzhydryl Compounds
Canagliflozin
Sodium-Glucose Transporter 2 Inhibitors
biology
business.industry
Candidiasis
biology.organism_classification
Corpus albicans
Mice, Inbred C57BL
medicine.anatomical_structure
chemistry
Urinary Tract Infections
Disease Progression
Female
SGLT2 Inhibitor
Tofogliflozin
business
medicine.drug
Subjects
Details
- ISSN :
- 14631326
- Volume :
- 16
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Diabetes, obesitymetabolism
- Accession number :
- edsair.doi.dedup.....6ea1efdd1f43489316c42259f669ed83