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Increased neurofilament light chain blood levels in neurodegenerative neurological diseases
- Source :
- PLoS ONE, Vol 8, Iss 9, p e75091 (2013), Gaiottino, J, Norgren, N, Dobson, R, Topping, J, Nissim, A, Malaspina, A, Bestwick, J P, Monsch, A U, Regeniter, A, Lindberg, R L, Kappos, L, Leppert, D, Petzold, A, Giovannoni, G & Kuhle, J 2013, ' Increased neurofilament light chain blood levels in neurodegenerative neurological diseases ', PLoS ONE, vol. 8, no. 9, e75091, pp. e75091 . https://doi.org/10.1371/journal.pone.0075091, PLoS ONE, 8(9):e75091. Public Library of Science, PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Objective: Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are cytoskeletal proteins of neurons and their release into cerebrospinal fluid has shown encouraging results as a biomarker for neurodegeneration. This study aimed to validate the quantification of the Nf light chain (NfL) in blood samples, as a biofluid source easily accessible for longitudinal studies. Methods: We developed and applied a highly sensitive electrochemiluminescence (ECL) based immunoassay for quantification of NfL in blood and CSF. Results: Patients with Alzheimer’s disease (AD) (30.8 pg/ml, n=20), Guillain-Barre-syndrome (GBS) (79.4 pg/ml, n=19) or amyotrophic lateral sclerosis (ALS) (95.4 pg/ml, n=46) had higher serum NfL values than a control group of neurological patients without evidence of structural CNS damage (control patients, CP) (4.4 pg/ml, n=68, p
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Neurofilament
lcsh:Medicine
Guillain-Barre Syndrome
Cerebrospinal fluid
Alzheimer Disease
Neurofilament Proteins
Internal medicine
medicine
Humans
Amyotrophic lateral sclerosis
lcsh:Science
Aged
Aged, 80 and over
Immunoassay
Multidisciplinary
medicine.diagnostic_test
Guillain-Barre syndrome
business.industry
Neurodegeneration
Amyotrophic Lateral Sclerosis
lcsh:R
Electrochemical Techniques
Middle Aged
medicine.disease
Endocrinology
Case-Control Studies
Luminescent Measurements
Biomarker (medicine)
Female
lcsh:Q
Alzheimer's disease
business
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....6e9f47e6b88e746e9fc1930d895a101b