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Quantitative myocardial perfusion SPECT/CT for the assessment of myocardial tracer uptake in patients with three-vessel coronary artery disease: Initial experiences and results
- Source :
- Journal of Nuclear Cardiology. 29:2511-2520
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background To evaluate quantitative myocardial perfusion SPECT/CT datasets for routine clinical reporting and the assessment of myocardial tracer uptake in patients with severe TVCAD. Methods MPS scans were reconstructed as quantitative SPECT datasets using CTs from internal (SPECT/CT, Q_INT) and external (PET/CT, Q_EXT) sources for attenuation correction. TPD was calculated and compared to the TPD from non-quantitative SPECT datasets of the same patients. SUVmax, SUVpeak, and SUVmean were compared between Q_INT and Q_EXT SPECT datasets. Global SUVmax and SUVpeak were compared between patients with and without TVCAD. Results Quantitative reconstruction was feasible. TPD showed an excellent correlation between quantitative and non-quantitative SPECT datasets. SUVmax, SUVpeak, and SUVmean showed an excellent correlation between Q_INT and Q_EXT SPECT datasets, though mean SUVmean differed significantly between the two groups. Global SUVmax and SUVpeak were significantly reduced in patients with TVCAD. Conclusions Absolute quantification of myocardial tracer uptake is feasible. The method seems to be robust and principally suitable for routine clinical reporting. Quantitative SPECT might become a valuable tool for the assessment of severe coronary artery disease in a setting of balanced ischemia, where potentially life-threatening conditions might otherwise go undetected.
- Subjects :
- Tomography, Emission-Computed, Single-Photon
Single Photon Emission Computed Tomography Computed Tomography
business.industry
Absolute quantification
Myocardial Perfusion Imaging
Ischemia
Coronary Artery Disease
For Attenuation Correction
medicine.disease
Perfusion
Coronary artery disease
Positron Emission Tomography Computed Tomography
medicine
Tracer uptake
Humans
Radiology, Nuclear Medicine and imaging
In patient
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Correction for attenuation
Subjects
Details
- ISSN :
- 15326551 and 10713581
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Nuclear Cardiology
- Accession number :
- edsair.doi.dedup.....6e9c7a8714a266c1aafcf7653c943981