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Anti-hypercholesterolemic and anti-hyperglycaemic effects of conventional and supercritical extracts of black cumin ( Nigella sativa )
- Source :
- Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 11, Pp 1014-1022 (2017)
- Publication Year :
- 2017
- Publisher :
- Medknow, 2017.
-
Abstract
- Objective To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black cumin. Methods Purposely, rat modelling was carried out for 2 months by designing three studies i.e. study I (normal rats), study II (hyperglycaemic rats) and study III (hypercholesterolemic rats). Each study was further divided into three groups based on diet i.e. control, functional diet (contained extract of black cumin prepared by using conventional solvent) and nutraceutical diet (contained extract of black cumin prepared by supercritical fluid extraction system). Results During whole trial, an abating trend was observed in the level of serum cholesterol with maximum reduction (12.8%) in nutraceutical group of study III. Low density lipoprotein and triglyceride level was also lowered maximum in study III as 17.1% and 11.6%, respectively. Whereas, highest decline in glucose level was in nutraceutical group of study II as 11.2%. Conclusions Inclusion of black cumin extracts in diet significantly lowers the occurrence of hyperglycaemia and hypercholesterolaemia. Furthermore, hypoglycaemic and hypocholesterolemic potential of nutraceutical diet is more prominent as compared to functional diet.
- Subjects :
- lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Nigella sativa
030204 cardiovascular system & hematology
01 natural sciences
Biochemistry, Genetics and Molecular Biology (miscellaneous)
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Nutraceutical
Functional food
medicine
Hyperglycaemia
Black cumin
lcsh:QH301-705.5
Thymoquinone
Hypercholesterolaemia
medicine.diagnostic_test
Traditional medicine
010405 organic chemistry
Supercritical fluid extraction
Supercritical fluid
0104 chemical sciences
Supercritical extract
lcsh:Biology (General)
chemistry
Low-density lipoprotein
Nutraceuticals
Lipid profile
Subjects
Details
- ISSN :
- 22211691
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Asian Pacific Journal of Tropical Biomedicine
- Accession number :
- edsair.doi.dedup.....6e987956ef6565a7a53fac4bda1d6a3e