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Exploring the therapeutic potentials of phyto-mediated silver nanoparticles formed via Calotropis procera (Ait.) R. Br. root extract
- Source :
- Journal of Experimental Nanoscience, Vol 15, Iss 1, Pp 217-231 (2020)
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- The objective of this work is to develop cost-effective, reliable, and large-scale production of metallic nanoparticles (NPs) by adopting green chemistry principles for industrial applications. In that view, we have studied the phytochemical reducibility of silver nitrate by making use of Calotropis Procera (Ait.) R. Br root extract, and based on its medicinal properties, an attempt was made to evaluate the therapeutic potentials of silver (Ag) NPs containing this plant extract towards the clinical strains of bacteria. The optimization studies on reducing the potentials were done considering the concentration, pH, temperature, and reaction period of both the extract and the metal precursor. The nanoarchitecture elements were interpreted using visual, spectroscopic, and microscopic analyses cohorting the antibacterial potentials towards the clinically significant strains. The antimicrobial activity exercised by these Ag NPs towards 10 different strains of medically important bacteria at a given concentration was proved to be significant. The antimicrobial potential was further validated quantitatively, and the MIC/MBC concentration values were determined. Finally, the cytotoxicity of Ag NPs when tested against the HEPK cell line indicated that the metal-phytochemical moiety exhibited the maximum therapeutic efficacy and thereby paving the way for the development of disruptive technologies in the field of nanomedicine.
- Subjects :
- Green chemistry
silver nanoparticles
Materials science
Biomedical Engineering
Bioengineering
02 engineering and technology
010402 general chemistry
lcsh:Chemical technology
01 natural sciences
antimicrobial assay
Silver nanoparticle
Calotropis procera
lcsh:TA401-492
General Materials Science
lcsh:TP1-1185
Metal nanoparticles
biology
green synthesis
021001 nanoscience & nanotechnology
biology.organism_classification
0104 chemical sciences
Antimicrobial assay
plant extract
cytotoxicity
lcsh:Materials of engineering and construction. Mechanics of materials
0210 nano-technology
calotropis procera
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 17458099 and 17458080
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Nanoscience
- Accession number :
- edsair.doi.dedup.....6e892bd1196e6dac1c9997e74759f9b3