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Hemorrhage and thrombus formation in early experimental osteonecrosis
- Source :
- Clinical orthopaedics and related research. (386)
- Publication Year :
- 2001
-
Abstract
- The aim of the current study was to test the hypothesis that the induction of an underlying immunologic condition in rabbits may enhance the development of steroid-induced osteonecrosis. Thirty-five adult rabbits were divided into four groups. Group I: 10 rabbits were immunized at 15-day intervals for 2 months by murine antibodies to deoxyribonucleic acid autoantibodies. Four weeks after the end of the immunization, the animals received injections of methylprednisolone for 7 days and then prednisolone per os for 8 months. Group II: 10 animals only received immunizations according to the protocol used in Group I. Group III: 10 animals only were treated with corticosteroids according to the protocol used in Group I. Group IV: five animals were used as controls. Various changes were observed in the proximal metaphysis and diaphysis of the femur in eight of 10 animals in Group I (80%) and in five of 10 animals in Group II (50%) when compared with the animals in Group III and Group IV. The most common feature was evidence of new and old hemorrhage through the sinusoids, exudative reaction and thrombus formation in veins and small arteries. Focal necrotic areas of bone marrow showed an accumulation of cell debris, residue of hemorrhage, and disappearance of marrow elements. These findings suggest that (1) corticosteroids may potentiate the effects of a preexisting condition to increase the risk of osteonecrosis; (2) immunologic reaction may be an important factor in the pathogenesis of necrotic lesions; and (3) repeated intramedullary hemorrhage and thrombus formation may represent early major pathologic findings in bone necrosis.
- Subjects :
- Photomicrography
Pathology
medicine.medical_specialty
Necrosis
Bone disease
medicine.drug_class
Hemorrhage
Methylprednisolone
Sensitivity and Specificity
Mice
Reference Values
medicine
Animals
Orthopedics and Sports Medicine
Femur
Thrombus
Autoantibodies
business.industry
Osteonecrosis
Thrombosis
General Medicine
medicine.disease
Disease Models, Animal
medicine.anatomical_structure
Prednisolone
Corticosteroid
Surgery
Female
Bone marrow
Rabbits
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 0009921X
- Issue :
- 386
- Database :
- OpenAIRE
- Journal :
- Clinical orthopaedics and related research
- Accession number :
- edsair.doi.dedup.....6e8733322845e50a922472b5838f28b9