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Stiffer Matrix Accelerates Migration of Hepatocellular Carcinoma Cells through Enhanced Aerobic Glycolysis Via the MAPK-YAP Signaling
- Source :
- Cancers, Cancers, Vol 12, Iss 2, p 490 (2020), Volume 12, Issue 2
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells are two fundamental mediators of tumor progression, including hepatocellular carcinoma (HCC). Yet, the correlation between ECM stiffness and excessive aerobic glycolysis in promoting the development of HCC remains unknown. Here, we demonstrated that stiffer ECM promotes HCC cell migration depending on their accelerated aerobic glycolysis. Our results also indicated that stiffer ECM-induced YAP activation plays a major role in promoting aerobic glycolysis of HCC cells. Moreover, we showed that JNK and p38 MAPK signaling are critical for mediating YAP activation in HCC cells. Together, our findings established that the MAPK-YAP signaling cascade that act as a mechanotransduction pathway is essential for promoting HCC cell aerobic glycolysis and migration in response to ECM stiffness.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
Cancer Research
Cell
migration
lcsh:RC254-282
Article
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
medicine
Mechanotransduction
aerobic glycolysis
mechanotransduction
Chemistry
Cell migration
hepatocellular carcinoma
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
digestive system diseases
Cell biology
030104 developmental biology
medicine.anatomical_structure
Oncology
Anaerobic glycolysis
Tumor progression
030220 oncology & carcinogenesis
Cancer cell
ECM stiffness
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....6e8200fb48f3cf6b0e2d298fa6700d21