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Heparan Sulfate in the Developing, Healthy, and Injured Lung
- Source :
- American Journal of Respiratory Cell and Molecular Biology. 55:5-11
- Publication Year :
- 2016
- Publisher :
- American Thoracic Society, 2016.
-
Abstract
- Remarkable progress has been achieved in understanding the regulation of gene expression and protein translation, and how aberrancies in these template-driven processes contribute to disease pathogenesis. However, much of cellular physiology is controlled by non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is to highlight the importance of a specific glycan polymer—the glycosaminoglycan heparan sulfate (HS)—on lung health and disease. We demonstrate how HS contributes to lung physiology and pathophysiology via its actions as both a structural constituent of the lung parenchyma as well as a regulator of cellular signaling. By highlighting current uncertainties in HS biology, we identify opportunities for future high-impact pulmonary and critical care translational investigations.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Cell physiology
Glycan
Cell signaling
Clinical Biochemistry
Biology
Lung injury
03 medical and health sciences
chemistry.chemical_compound
Animals
Humans
Lung
Molecular Biology
Regulation of gene expression
Lung Injury
Cell Biology
Heparan sulfate
Cell biology
Translational Review
030104 developmental biology
Proteoglycan
chemistry
Acute Disease
Chronic Disease
Immunology
biology.protein
Heparitin Sulfate
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 15354989 and 10441549
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology
- Accession number :
- edsair.doi.dedup.....6e7eb4385309e8d7cf2f193778837364