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Prognostic Value of the Circumferential Resection Margin in Esophageal Cancer Patients After Neoadjuvant Chemoradiotherapy
- Source :
- Annals of Surgical Oncology, Annals of Surgical Oncology, 22, S1301-S1309. SPRINGER
- Publication Year :
- 2015
-
Abstract
- Background. Circumferential resection margins (CRM) for esophageal cancer (EC), defined by the College of American Pathologists (CAP; >0 mm) or the Royal College of Pathologists (RCP; >1 mm) as tumor-free (R0), are based on a surgery-alone approach. We evaluated the usefulness of both definitions in current practice with neoadjuvant chemoradiotherapy (nCRT).Methods. CRMs were measured in 209 patients (104 with nCRT) with locally advanced EC after transthoracic esophagectomy. Local recurrence and cancer related death were scored as events. Patients were followed for at least 2 years or until death. Prognostic factors (P Results. Independent prognostic factors (P Conclusions. nCRT affected the CRM cutoff values. After nCRT, the CRM R0 according to the CAP was only prognostic for 2-year LRFS. However, in the surgery-alone group, it was prognostic for both the 2-year DFS and LRFS.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Esophageal Neoplasms
CARCINOMA
SURGERY
medicine.medical_treatment
THERAPY
Specimen Handling
CHEMORADIATION
Internal medicine
Medicine
Humans
CRITERIA
Prospective Studies
Stage (cooking)
Thoracic Oncology
Survival rate
Neoadjuvant therapy
JUNCTIONAL CANCER
METAANALYSIS
Aged
Neoplasm Staging
Retrospective Studies
Univariate analysis
INVOLVEMENT FOLLOWING ESOPHAGECTOMY
business.industry
ADENOCARCINOMA
Chemoradiotherapy
Esophageal cancer
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Neoadjuvant Therapy
Esophagectomy
Survival Rate
Surgical Procedures, Operative
SURVIVAL
Adenocarcinoma
Female
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 10689265
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....6e7d70b123f0967472626dc1c6a9c260