Relationship of maternal creatinine to first neonatal creatinine in infants <30 weeks gestation

To examine the relationship between maternal and neonatal creatinine (Cr) in preterm infants in the context of antenatal and intrapartum maternal and neonatal factors. In this 5&#189;-year, single-center, retrospective study, paired maternal and neonatal Cr were compared by t-test. Linear regression for correlated outcomes employing generalized estimating equations was used to examine neonatal Cr as a function of antenatal maternal Cr and potential confounders. A total of 157 neonates of 124 mothers met study criteria. Neonatal Cr values in the first 24 h of life were significantly higher than antenatal maternal values. Linear regression modeling showed that maternal Cr, neonatal lactate, hypoxic–ischemic villous changes on placental pathology and multiple gestation were each significant determinants of the first neonatal Cr. No neonatal Cr was less than its paired maternal value. Maternal Cr, neonatal lactate, hypoxic–ischemic villous changes in the placenta and multiple gestation were each significantly associated with neonatal Cr.