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Speckle Tracking Analysis Reveals Altered Left Atrial and Ventricular Myocardial Deformation in Patients with End-Stage Liver Disease
- Source :
- Journal of Clinical Medicine, Volume 10, Issue 5, Journal of Clinical Medicine, Vol 10, Iss 897, p 897 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Background: Cardiac function can be influenced by liver cirrhosis and should be thoroughly evaluated before liver transplantation. We investigated left ventricular (LV) and, for the first time, left atrial (LA) strain and strain rate in end-stage liver cirrhosis patients of different etiologies. Methods: This retrospective, cross-sectional study evaluated left heart function in 80 cirrhosis patients and 30 controls using standardized echocardiographic techniques and speckle tracking technology (STE) analysis. Serum markers of liver function were used for correlation analysis. Results: While conventional parameters demonstrated no alteration in systolic function, speckle tracking analysis showed a significant increase in LV longitudinal strain throughout all cardiac layers, with significant correlation to model of end-stage liver disease (MELD) score. LA reservoir and conduit strain as well as LA strain rate in all phases were significantly reduced in end-stage liver disease (ESLD) patients compared to control. STE for the evaluation of LA phasic function seemed to be more sensitive than volumetric methods. Kaplan-Meier curves showed a trend towards reduced post-transplant survival in patients with a reduced LA reservoir and conduit strain. Conclusion: STE analysis detected increased LV and decreased LA deformation in cirrhosis patients, thus proving to be highly sensitive to cardiac changes and useful for more precise cardiac evaluation.
- Subjects :
- Cardiac function curve
medicine.medical_specialty
Cirrhosis
left ventricle
medicine.medical_treatment
lcsh:Medicine
Strain (injury)
030204 cardiovascular system & hematology
Liver transplantation
Article
left atrium
03 medical and health sciences
Liver disease
Speckle pattern
0302 clinical medicine
strain
Internal medicine
medicine
business.industry
lcsh:R
General Medicine
medicine.disease
Cirrhotic cardiomyopathy
speckle tracking
Cardiology
cirrhotic cardiomyopathy
030211 gastroenterology & hepatology
Liver function
business
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....6e58b152a4e018b7783327270277a747
- Full Text :
- https://doi.org/10.3390/jcm10050897