Back to Search
Start Over
Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2020
- Publisher :
- Spandidos Publications, 2020.
-
Abstract
- Cognitive impairment and neuro-inflammatory responses are the distinctive characteristics of Alzheimer's disease (AD). Tormentic acid (TA) is one of the major active components of Potentilla chinensis and has been demonstrated to have anti-inflammatory properties. However, the potential effects of TA on neuro-inflammatory responses and memory impairment in AD remain unknown. The present study investigated the therapeutic effect of TA on neuro-inflammation, as well as learning and memory impairment in AD mice. In addition, the effects of TA treatment were also examined in a co-culture system of microglia and primary neurons. Intraperitoneal administration of TA attenuated memory deficits in amyloid β precursor protein/presenilin 1 transgenic mice, with a marked decrease in amyloid plaque deposition. TA also reduced microglial activation and decreased the secretion of pro-inflammatory factors in AD mice. Furthermore, pre-treatment with TA suppressed the production of pro-inflammatory markers, as well as the nuclear translocation of nuclear factor-κB (NF-κB) p65 induced by Aβ exposure in BV2 cells. TA also reduced inhibited neurotoxicity and improved neuron survival in a neuron-microglia co-culture system. Taken together, these findings suggested that TA could attenuate neuro-inflammation and memory impairment, which may be closely associated with regulation of the NF-κB pathway.
- Subjects :
- Male
0301 basic medicine
Genetically modified mouse
Cancer Research
Tormentic acid
nuclear factor-κB
microglia
Mice, Transgenic
Plaque, Amyloid
Inflammation
Pharmacology
Biochemistry
Neuroprotection
Presenilin
Cell Line
Amyloid beta-Protein Precursor
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Alzheimer Disease
Presenilin-1
Genetics
medicine
Animals
Memory impairment
Maze Learning
Molecular Biology
Neurons
Memory Disorders
tormentic acid
Microglia
Chemistry
NF-kappa B
Neurotoxicity
Articles
Alzheimer's disease
medicine.disease
Triterpenes
Disease Models, Animal
Neuroprotective Agents
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Molecular Medicine
medicine.symptom
Injections, Intraperitoneal
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....6e4efcf54397625f55cc38677a145855