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The absence of exanthema is related with death and illness severity in acute enterovirus infection
- Source :
- International Journal of Infectious Diseases, Vol 28, Iss C, Pp 123-125 (2014)
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Summary Objective To clarify whether exanthema is related to illness severity in acute enterovirus infection in children. Methods The data of pediatric inpatients at Zhujiang Hospital during 2009–2012 with an acute enterovirus infection were reviewed retrospectively. Enterovirus infection was determined by real-time reverse transcription PCR. Clinical data were summarized and compared between cases with and without exanthema. Results A total of 780 pediatric inpatients with an acute enterovirus infection were included in this study, of whom 83 (10.6%) presented no exanthema. The percentage of deaths in the group of patients without exanthema was significantly higher than that in the group with exanthema (7.2% vs. 1.1%; p = 0.002). Central nervous system involvement (41.0% vs. 30.0%; p = 0.041), severe central nervous system (CNS) involvement (21.7% vs. 11.0%; p = 0.005), severe CNS involvement with cardiopulmonary failure (9.6% vs. 2.3%; p = 0.002), an altered level of consciousness (15.7% vs. 7.6%; p = 0.013), and convulsions (14.4% vs. 6.3%; p = 0.007) occurred significantly more frequently in the group without exanthema. Conclusions A considerable proportion of children with an acute enterovirus infection in Guangdong Province, China during 2009–2012 presented no exanthema, and the absence of exanthema was found to be related to death and illness severity for these acute enterovirus infections. Clinicians in China should consider enterovirus as the possible pathogen when treating children with an acute pathogen infection without exanthema.
- Subjects :
- Male
Microbiology (medical)
China
medicine.medical_specialty
Enterovirus Infections
CNS Involvement
medicine.disease_cause
Severity
lcsh:Infectious and parasitic diseases
Internal medicine
medicine
Humans
Illness severity
lcsh:RC109-216
Pathogen
Illness
Retrospective Studies
Enterovirus
business.industry
Infant
General Medicine
Exanthema
Death
Infectious Diseases
Child, Preschool
Acute Disease
Immunology
Female
medicine.symptom
business
Altered level of consciousness
Subjects
Details
- ISSN :
- 12019712
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....6e49abfac70ec584787be17494ee3ad6