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Vitamin D deficiency in hepatitis C virus infection: what is old? what is new?
- Source :
- European journal of gastroenterologyhepatology. 30(7)
- Publication Year :
- 2018
-
Abstract
- In the past few years, a growing body of clinical evidence has highlighted the risk of vitamin D deficiency in patients with chronic hepatitis C and that vitamin D levels are associated with the course of hepatitis C virus (HCV) infection, adverse effects, and treatment response to peginterferon/ribavirin. Recently, studies have found that vitamin D status is related to drug resistance and increased risk of infection in patients with liver cirrhosis. Vitamin D-related gene polymorphisms have been found to explain the interactions between vitamin D deficiency and HCV infection, offering a new perspective toward understanding the current problems such as the development of insulin resistance and racial differences in sustained virological response. Studies have been conducted to determine whether vitamin D supplementation as an adjuvant yields a better result compared with traditional HCV treatment. Here, we provide a brief review of the past and present knowledge of vitamin D in HCV infection.
- Subjects :
- Vitamin
Cirrhosis
Sustained Virologic Response
Hepatitis C virus
Hepacivirus
medicine.disease_cause
Antiviral Agents
vitamin D deficiency
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Drug Resistance, Viral
medicine
Vitamin D and neurology
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
Vitamin D
Hepatitis
Polymorphism, Genetic
Hepatology
business.industry
Ribavirin
Gastroenterology
virus diseases
Hepatitis C
Hepatitis C, Chronic
medicine.disease
Vitamin D Deficiency
Phenotype
Treatment Outcome
chemistry
Immunology
Dietary Supplements
030211 gastroenterology & hepatology
business
Biomarkers
Subjects
Details
- ISSN :
- 14735687
- Volume :
- 30
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- European journal of gastroenterologyhepatology
- Accession number :
- edsair.doi.dedup.....6e3f4c4533cfaf7b4fdb1610eb3b2f6b