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Accurate quantification methods to evaluate cervical cord atrophy in multiple sclerosis patients
- Source :
- MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), r-FISABIO. Repositorio Institucional de Producción Científica, instname
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Object: Automatic accurate measurement techniques are needed to increase reproducibility in the quantification of cervical cord area (CCA) with magnetic resonance (MR) imaging in the assessment of central nervous system (CNS) atrophy in multiple sclerosis (MS) patients. Materials and methods: Two segmentation methods were implemented: (1) spatial mean brightness level estimation (SMBLE), and (2) partial-volume modeling (PVM). These were evaluated with the inclusion of spinal cord inclination and/or partial-volume-effect corrections. An averaged manually segmented set was considered as reference. Thirty MR studies were used to compare the different methods. A set of 15 MS patients and 15 control subjects within a two-year longitudinal study were used to evaluate cord atrophy with the best method. Statistical evaluation was made by using an intraclass correlation coefficient and Bland–Altman comparisons. Results: Partial-volume modeling with spinal cord inclination correction and partial-volume spinal-cord contour contribution estimation was the most accurate method. The longitudinal test showed a 4% decrease in CCA in MS patients with no significant reduction in control subjects. Conclusion: The automatic PVM cord-segmentation approach, taking into consideration the spinal-cord inclination and partial-volume treatment, provides reproducibility and increased accuracy in the evaluation of cord atrophy, allowing the monitoring of changes in MS patients.
- Subjects :
- Adult
Central Nervous System
Male
medicine.medical_specialty
Multiple Sclerosis
Cord
Adolescent
Intraclass correlation
Central nervous system
Biophysics
multiple sclerosis
Spinal Cord Diseases
Atrophy
atrophy
medicine
Humans
Radiology, Nuclear Medicine and imaging
cervical cord
Cerebrospinal Fluid
Reproducibility
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Multiple sclerosis
Reproducibility of Results
Magnetic resonance imaging
medicine.disease
Spinal cord
Magnetic Resonance Imaging
Surgery
medicine.anatomical_structure
Case-Control Studies
Calibration
Female
Nuclear medicine
business
Software
MRI
Subjects
Details
- ISSN :
- 13528661 and 09685243
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance Materials in Physics, Biology and Medicine
- Accession number :
- edsair.doi.dedup.....6e3b1ba3932660d5dd4a1a769dd83a94