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Advances in the medical management of paediatric IBD
- Source :
- Nature Reviews Gastroenterology & Hepatology. 11:99-108
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- IBD includes two classic entities, Crohn's disease and ulcerative colitis, and a third undetermined form (IBD-U), characterized by a chronic relapsing course resulting in a high rate of morbidity and impaired quality of life. Children with IBD are vulnerable in terms of growth failure, malnutrition and emotional effects. The aims of therapy have now transitioned from symptomatic control to the achievement of mucosal healing and deep remission. This type of therapy has been made possible by the advent of disease-modifying drugs, such as biologic agents, which are capable of interrupting the inflammatory cascade underlying IBD. Biologic agents are generally administered in patients who are refractory to conventional therapies. However, there is growing support that such agents could be used in the initial phases of the disease, typically in paediatric patients, to interrupt and cease the inflammatory process. Until several years ago, most therapeutic programmes in paediatric patients with IBD were borrowed from adult trials, whereas paediatric studies were often retrospective and uncontrolled. However, guidelines on therapeutic management of paediatric IBD and controlled, prospective, randomized trials including children with IBD have now been published. Here, the current knowledge concerning treatment options for children with IBD are reported. We also highlight the effectiveness and safety of new therapeutic advances in these paediatric patients.© 2014 Macmillan Publishers Limited. All rights reserved.
- Subjects :
- medicine.medical_specialty
Adolescent
MEDLINE
Ulcerative
Disease
Inflammatory bowel disease
law.invention
Immunomodulation
Crohn Disease
Quality of life
Randomized controlled trial
law
Humans
Medicine
Child
Preschool
Intensive care medicine
Adverse effect
Age Factors
Biological Therapy
Child, Preschool
Colitis, Ulcerative
Inflammatory Bowel Diseases
Nutrition Therapy
Treatment Outcome
Gastroenterology
Hepatology
business.industry
Colitis
medicine.disease
Ulcerative colitis
digestive system diseases
Malnutrition
Physical therapy
business
Subjects
Details
- ISSN :
- 17595053 and 17595045
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Gastroenterology & Hepatology
- Accession number :
- edsair.doi.dedup.....6e3aaf3f7013e2d0e4572f5040cc6b6a