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Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance
- Source :
- Radiology. 185(3)
- Publication Year :
- 1992
-
Abstract
- Brain tumor metabolism was studied with hydrogen-1 magnetic resonance spectroscopy and positron emission tomography with fluorine-18 fluorodeoxyglucose in 50 patients. N-acetylaspartate (NAA) was generally decreased in tumors and radiation necrosis but was somewhat preserved at neoplasm margins. Choline was increased in most solid tumors. Solid high-grade gliomas had higher normalized choline values than did solid low-grade gliomas (P < .02), but the normalized choline value was not a discriminator of tumor grade, since necrotic high-grade lesions had reduced choline values. Serial studies in one case showed an increase in choline as the glioma underwent malignant degeneration. Choline values were lower in chronic radiation necrosis than in solid anaplastic tumors (P < .001). In two cases studied before and after treatment, clinical improvement and a reduction in choline followed therapy. Lactate is more likely to be found in high-grade gliomas, but its presence is not a reliable indicator of malignancy.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Adolescent
medicine.medical_treatment
Brain tumor
Malignancy
Choline
chemistry.chemical_compound
Glioma
medicine
Humans
Radiology, Nuclear Medicine and imaging
Lactic Acid
Aged
Fluorodeoxyglucose
Aspartic Acid
medicine.diagnostic_test
business.industry
Brain Neoplasms
Brain
Magnetic resonance imaging
Middle Aged
medicine.disease
Creatine
Magnetic Resonance Imaging
Radiation therapy
Glucose
chemistry
Positron emission tomography
Lactates
Female
Nuclear medicine
business
medicine.drug
Tomography, Emission-Computed
Subjects
Details
- ISSN :
- 00338419
- Volume :
- 185
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Radiology
- Accession number :
- edsair.doi.dedup.....6e148bff10f36d36f7219f7b1161220b