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Iron deposition in autopsied liver on patients receiving long-term TPN
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 8, p e0237104 (2020)
- Publication Year :
- 2020
- Publisher :
- PLOS, 2020.
-
Abstract
- BackgroundVitamins and minerals are routinely administered by total parenteral nutrition (TPN). However, in Japan, adjustments in iron dosage are difficult because blended mineral preparations are often used. It is therefore unclear whether the iron content is appropriate in cases of long-term TPN. The aim of the study was to assess the influence of iron administration by long-term TPN on iron deposition in post-mortem liver samples isolated from older deceased patients.MethodsLiver tissues were collected from post-mortem autopsies of 187 patients over a period of 15 years. Samples were stained with Prussian blue and histologically evaluated from Grade 0-V by at least three different observers. Specimens with positive and negative iron staining were compared, and positive samples were grouped according to the level and distribution of the staining. Post-mortem blood obtained from the subclavian vein during autopsy was also analysed. Samples were collected for the measurement of unsaturated serum iron, serum iron, albumin, prealbumin, hepcidin, and IL-6 concentrations.ResultsIron accumulation in the liver was significantly higher in male patients (p = 0.005) with a history of surgery (p = 0.044) or central vein administration of iron (pConclusionsChronic intravenous administration of iron was associated with iron deposition in the liver, even when given the minimum recommended dosage. In long-term TPN patients, the iron dose should therefore be carefully considered.
- Subjects :
- Male
Parenteral Nutrition
Physiology
Gastroenterology
Biochemistry
Negative Staining
White Blood Cells
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Group-Specific Staining
Infusions, Intravenous
Aged, 80 and over
Staining
Multidisciplinary
biology
medicine.diagnostic_test
Body Fluids
Chemistry
medicine.anatomical_structure
Blood
Liver
030220 oncology & carcinogenesis
Physical Sciences
Serum iron
Medicine
030211 gastroenterology & hepatology
Female
Autopsy
Prussian Blue Staining
Cellular Types
Anatomy
Research Article
Chemical Elements
medicine.medical_specialty
Kupffer Cells
Science
Iron
Immune Cells
Immunology
Research and Analysis Methods
03 medical and health sciences
Hepcidin
Internal medicine
medicine
Humans
Vein
Aged
Nutrition
Ferritin
Blood Cells
business.industry
Albumin
Biology and Life Sciences
Proteins
Protein Complexes
Cell Biology
Transthyretin
Parenteral nutrition
Specimen Preparation and Treatment
biology.protein
Hepatocytes
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....6e07c6bf24853b495b49638cc5a7b766