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Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones
- Source :
- Andrologia. 51
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.
- Subjects :
- Male
Pituitary gland
medicine.medical_specialty
Peptide Hormones
Urology
Neuropeptide
Hypothalamic–pituitary–gonadal axis
Male sex hormones
Biology
Gonadotropin-Releasing Hormone
Endocrinology
Internal medicine
medicine
Animals
Nucleobindins
Testosterone
Rats, Wistar
Hypothalamic Hormones
Reproductive hormones
General Medicine
medicine.anatomical_structure
Hypothalamus
Gonadotropins, Pituitary
Hormone
Subjects
Details
- ISSN :
- 14390272 and 03034569
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Andrologia
- Accession number :
- edsair.doi.dedup.....6dd8c5e17edb4c32e0bceef2412c28f4