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Negative impact of pretreatment anemia on local control after neoadjuvant chemoradiotherapy and surgery for rectal cancer
- Source :
- Radiation Oncology Journal
- Publication Year :
- 2012
- Publisher :
- The Korean Society for Radiation Oncology, 2012.
-
Abstract
- Purpose: Although anemia is considered to be a contributor to intra-tumoral hypoxia and tumor resistance to ionizing radiation in cancer patients, the impact of pretreatment anemia on local control after neoadjuvant concurrent chemoradiotherapy (NACRT) and surgery for rectal cancer remains unclear. Materials and Methods: We reviewed the records of 247 patients with locally advanced rectal cancer who were treated with NACRT followed by curative-intent surgery. Results: The patients with anemia before NACRT (36.0%, 89/247) achieved less pathologic complete response (pCR) than those without anemia (p = 0.012). The patients with pretreatment anemia had worse 3-year local control than those without pretreatment anemia (86.0% vs. 95.7%, p = 0.005). Multivariate analysis showed that pretreatment anemia (p = 0.035), pathologic tumor and nodal stage (p = 0.020 and 0.032, respectively) were independently significant factors for local control. Conclusion: Pretreatment anemia had negative impacts on pCR and local control among patients who underwent NACRT and surgery for rectal cancer. Strategies maintaining hemoglobin level within normal range could potentially be used to improve local control in rectal cancer patients.
- Subjects :
- medicine.medical_specialty
Anemia
business.industry
Colorectal cancer
medicine.medical_treatment
Hypoxia (medical)
medicine.disease
Surgery
Concurrent chemoradiotherapy
Oncology
Neoadjuvant therapy
medicine
Radiology, Nuclear Medicine and imaging
Original Article
Hemoglobin
Clinical Investigation
medicine.symptom
Rectal cancer
business
Complete response
Neoadjuvant chemoradiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 22343164 and 22341900
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology Journal
- Accession number :
- edsair.doi.dedup.....6dd403957e53ec3ea43ac02e5d2f4f0c