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Hypereosinophilia with Concurrent Venous Thromboembolism: Clinical Features, Potential Risk Factors, and Short-term Outcomes in a Chinese Cohort
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Idiopathic hypereosinophilia (IHE) and hypereosinophilic syndrome (HES) are benign haematological disorders. Studies have suggested that venous thromboembolism (VTE) is a rare but sometimes fatal complication of hypereosinophilia; however, data are limited. We retrospectively analysed clinical features and short-term outcomes of 63 consecutive patients (82.5% men; mean age, 40.92 ± 10.89 years) with IHE or HES with concurrent VTE from January 1998 through December 2018. Risk factors for pulmonary embolism (PE) were explored by multivariate logistic analysis. DVT and/or PE was detected by imaging in all patients. Independent risk factors for PE were a body mass index of >24.1 kg/m2 (odds ratio [OR]: 5.62, 95% confidence interval [CI]: 1.21–26.13, P = 0.028), peak absolute eosinophil count of >6.3 × 109/L (OR: 5.55, 95% CI: 1.292–23.875, P = 0.021), and >13.9-month duration of hypereosinophilia (OR: 4.51, 95% CI: 1.123–18.09, P = 0.034). All patients were treated with corticosteroids and anticoagulants. The short-term hypereosinophilia remission rate was 100%; no recurrent VTE or major bleeding was observed. Hypereosinophilia is a potential risk factor for VTE. PE in patients with IHE/HES and DVT is associated with a higher body mass index, higher peak absolute eosinophil count, and longer duration of hypereosinophilia. Corticosteroids and anticoagulants provided effective short-term control of hypereosinophilia and VTE.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
lcsh:Medicine
Hypereosinophilia
030204 cardiovascular system & hematology
Article
03 medical and health sciences
Leukocyte Count
0302 clinical medicine
Recurrence
Risk Factors
Internal medicine
hemic and lymphatic diseases
Thromboembolism
Hypereosinophilic Syndrome
medicine
Humans
lcsh:Science
Glucocorticoids
Retrospective Studies
Multidisciplinary
business.industry
Hypereosinophilic syndrome
lcsh:R
Anticoagulants
Odds ratio
Venous Thromboembolism
Middle Aged
medicine.disease
Confidence interval
Pulmonary embolism
Eosinophils
030220 oncology & carcinogenesis
Cohort
lcsh:Q
Drug Therapy, Combination
Female
medicine.symptom
Complication
business
Pulmonary Embolism
Body mass index
Haematological diseases
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....6dc2cc98ca5d07213f6889c67377d89e