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Synchronous primary cancers of the endometrium and ovary: a single institution review of 84 cases
- Source :
- Gynecologic Oncology. 94:456-462
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Objectives . Synchronous primary cancers of the endometrium and ovary are found in 10% of women with ovarian cancer and 5% of women with endometrial cancer. The purpose of this study was to characterize patients diagnosed with synchronous primary cancers of the endometrium and ovary with an emphasis on risk factors. Methods . Between 1989 and 2002, 84 patients with synchronous primary cancers of the endometrium and ovary were identified. Patients with uterine papillary serous carcinoma were excluded. Clinical and pathologic information was obtained from medical records. Parametric methods were used to compare clinical and pathologic features. Kaplan–Meier survival analyses were performed and compared using the log rank test. Results . Median age at diagnosis was 50 years. Median body mass index (BMI) was 28 kg/m 2 . Fifty-one percent (43/84) of the women were premenopausal and 33% (28/84) were nulliparous. The most common presenting symptom was abnormal vaginal bleeding; in those women with abnormal vaginal bleeding, 69% had stage I ovarian cancer. Ovarian cancer was an incidental finding in 48% of these patients. Sixty-eight percent of patients (57/84) had endometrioid histology of both their endometrial and ovarian cancers. Patients with early stage ovarian cancer tended to have a more favorable prognosis than those with advanced stage disease (median survival not reached in stage I and II versus 66 months in stage III and IV, P = 0.06). Patients with concordant endometrioid histology had a favorable prognosis (median survival 119 versus 48 months in all other groups, P = 0.02). Conclusions . In this large series of patients, women with synchronous primary cancers of the endometrium and ovary were young, obese, nulliparous, and premenopausal. Patients with concordant endometrioid tumors of the endometrium and ovary had a favorable prognosis, with median survival approaching 10 years.
- Subjects :
- Adult
medicine.medical_specialty
Ovary
Endometrium
Cohort Studies
Neoplasms, Multiple Primary
Risk Factors
medicine
Carcinoma
Humans
Vaginal bleeding
Stage (cooking)
Aged
Aged, 80 and over
Ovarian Neoplasms
Gynecology
business.industry
Endometrial cancer
Obstetrics and Gynecology
Middle Aged
Prognosis
medicine.disease
female genital diseases and pregnancy complications
Endometrial Neoplasms
medicine.anatomical_structure
Oncology
Female
Median body
medicine.symptom
business
Ovarian cancer
Carcinoma, Endometrioid
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....6dbe047724a2c74b41cb6a40c93fce23