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Computed Tomography and Magnetic Resonance Imaging for Longitudinal Characterization of Lung Structure Changes in a Yucatan Miniature Pig Silicosis Model
- Source :
- Toxicologic pathology. 44(3)
- Publication Year :
- 2016
-
Abstract
- Medical imaging is a rapidly advancing field enabling the repeated, noninvasive assessment of physiological structure and function. These beneficial characteristics can supplement studies in swine by mirroring the clinical functions of detection, diagnosis, and monitoring in humans. In addition, swine may serve as a human surrogate, facilitating the development and comparison of new imaging protocols for translation to humans. This study presents methods for pulmonary imaging developed for monitoring pulmonary disease initiation and progression in a pig exposure model with computed tomography and magnetic resonance imaging. In particular, a focus was placed on systematic processes, including positioning, image acquisition, and structured reporting to monitor longitudinal change. The image-based monitoring procedure was applied to 6 Yucatan miniature pigs. A subset of animals ( n = 3) were injected with crystalline silica into the apical bronchial tree to induce silicosis. The methodology provided longitudinal monitoring and evidence of progressive lung disease while simultaneously allowing for a cross-modality comparative study highlighting the practical application of medical image data collection in swine. The integration of multimodality imaging with structured reporting allows for cross comparison of modalities, refinement of CT and MRI protocols, and consistently monitors potential areas of interest for guided biopsy and/or necropsy.
- Subjects :
- medicine.medical_specialty
Biomedical Research
Swine
Silicosis
Computed tomography
Toxicology
Article
030218 nuclear medicine & medical imaging
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Structured reporting
medicine
Medical imaging
Animals
Molecular Biology
Lung
medicine.diagnostic_test
business.industry
Histocytochemistry
Magnetic resonance imaging
Cell Biology
medicine.disease
Magnetic Resonance Imaging
Lung structure
Disease Models, Animal
030220 oncology & carcinogenesis
Yucatan Miniature pig
Swine, Miniature
Female
Radiology
business
Tomography, X-Ray Computed
Preclinical imaging
Subjects
Details
- ISSN :
- 15331601
- Volume :
- 44
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Toxicologic pathology
- Accession number :
- edsair.doi.dedup.....6dbbaea0cec62ae092c8ab4bd2ad0b3d