Back to Search
Start Over
Epigenetic modifications and long noncoding RNAs influence pancreas development and function
- Source :
- Trends in genetics : TIG. 31(6)
- Publication Year :
- 2015
-
Abstract
- Insulin-producing β cells within the pancreatic islet of Langerhans are responsible for maintaining glucose homeostasis; the loss or malfunction of β cells results in diabetes mellitus. Recent advances in cell purification strategies and sequencing technologies as well as novel molecular tools have revealed that epigenetic modifications and long noncoding RNAs (lncRNAs) represent an integral part of the transcriptional mechanisms regulating pancreas development and β cell function. Importantly, these findings have uncovered a new layer of gene regulation in the pancreas that can be exploited to enhance the restoration and/or repair of β cells to treat diabetes.
- Subjects :
- Cellular differentiation
Biology
Article
Epigenesis, Genetic
Islets of Langerhans
Insulin-Secreting Cells
Genetics
medicine
Glucose homeostasis
Animals
Humans
Epigenetics
Regulation of gene expression
geography
geography.geographical_feature_category
Models, Genetic
Endoderm
Gene Expression Regulation, Developmental
Cell Differentiation
Islet
Cell biology
medicine.anatomical_structure
RNA, Long Noncoding
Pancreas
Function (biology)
Subjects
Details
- ISSN :
- 01689525
- Volume :
- 31
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Trends in genetics : TIG
- Accession number :
- edsair.doi.dedup.....6db843b12e0bd36be96ef1005944326e