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Investigation of the protective effect of gel incorporating Eugenia jambolana leaf extract on 5-fluorouracil-induced oral mucositis: an animal study
- Source :
- Journal of Cancer Research and Clinical Oncology. 148:2153-2162
- Publication Year :
- 2022
- Publisher :
- Springer Science and Business Media LLC, 2022.
-
Abstract
- Purpose The study aimed to evaluate the possible preventive effect of two concentrations (3 and 5% w/w) of Eugenia jambolana (EJ) extract against 5-FU-induced mucositis. Method Sixteen adult rats were separated into four groups: two control and two preventive groups. Animals in Groups 1, 2, and 3 were injected intraperitoneally with 60 mg/kg/day of 5-FU on Day 1 followed by 150 mg/kg/day on Day 5. The rats in Group 4 (negative control) were given physiological saline at the same times and doses. Furthermore, on the fifth day of the study, the cheek and sublingual mucosa were irritated by external superficial scratches using the tip of an 18-G needle, followed by the application 15 µL of 20% acetic acid, after which 3 and 5% EJ w/w gels were applied topically for animals in Groups 2 and 3, respectively. Results The weight and the mucositis scores were recorded. Antioxidant and anti-inflammatory markers and biochemical tests were analyzed. Significant differences were found between the study groups in weight loss, clinical mucositis scores, mortality rates, and antioxidant and anti-inflammatory parameters. Conclusion The preventive effect of 3% gel was significant, with no mortality rate, making it an option for preventive strategies. WOS:000800703000002 2-s2.0-85130847543 PMID: 35622166
- Subjects :
- Internal Diseases
Mucositis
Cancer Research
Anti-infammatory
Syzygium
NF-KAPPA-B
Anti-Inflammatory Agents
Sağlık Bilimleri
Anti - infammatory
İç Hastalıkları
Clinical Medicine (MED)
Antioxidants
Health Sciences
MANAGEMENT
Animals
Chemotherapy
Klinik Tıp (MED)
OXIDATIVE STRESS
Stomatitis
Gel
Internal Medicine Sciences
Klinik Tıp
PLASMA
Plant Extracts
Dahili Tıp Bilimleri
General Medicine
CLINICAL MEDICINE
INTERLEUKIN-10
Onkoloji
Tıp
Rats
Eugenia Jambolana
Oncology
Medicine
ONKOLOJİ
Eugenia jambolana
Fluorouracil
Anti-inflammatory
Antioxidant
Gels
Subjects
Details
- ISSN :
- 14321335 and 01715216
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer Research and Clinical Oncology
- Accession number :
- edsair.doi.dedup.....6db5e8dc55fcd3464af4b1a304396e43