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Validation of combined Monte Carlo and photokinetic simulations for the outcome correlation analysis of benzoporphyrin derivative-mediated photodynamic therapy on mice

Authors :
Timothy C. Zhu
Mary Potasek
Michele M. Kim
Karl W. Beeson
Evgueni Parilov
Source :
Journal of Biomedical Optics
Publication Year :
2019
Publisher :
Society of Photo-Optical Instrumentation Engineers, 2019.

Abstract

We compare previously reported benzoporphyrin derivative (BPD)-mediated photodynamic therapy (PDT) results for reactive singlet oxygen concentration (also called singlet oxygen dose) on mice with simulations using a computational device, Dosieā„¢, that calculates light transport and photokinetics for PDT in near real-time. The two sets of results are consistent and validate the use of the device in PDT treatment planning to predict BPD-mediated PDT outcomes in mice animal studies based on singlet oxygen dose, which showed a much better correlation with the cure index than the conventional light dose.

Details

Language :
English
ISSN :
15602281 and 10833668
Volume :
24
Issue :
3
Database :
OpenAIRE
Journal :
Journal of Biomedical Optics
Accession number :
edsair.doi.dedup.....6dae10a0856ae074bd304215898e85f4