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Brachial-ankle pulse wave velocity predicts decline in renal function and cardiovascular events in early stages of chronic kidney disease
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2013
-
Abstract
- Objective: In this study, we investigated the predictive capacity of the brachial–ankle aortic pulse wave velocity (baPWV), a marker of arterial stiffness, for the decline in renal function and for cardiovascular events in the early stages of chronic kidney disease (CKD). Method: Two hundred forty-one patients who underwent a comprehensive check-up were included and were divided into two groups according to their estimated glomerular filtration rates (eGFR): patients with CKD categories G2, G3a and G3b (30 ≤ eGFR < 90 ml/min/1.73m 2 , eGFR < 90 group; n=117) and those with eGFR ≥ 90 ml/min/1.73 m 2 (eGFR ≥ 90 group; n=124). The change in renal function, the eGFR change, was determined by the slope of eGFR against time. We analysed whether baPWV was associated with eGFR change or predicted cardiovascular events. Results: baPWV was independently associated with eGFR change in a multivariate analysis of the total patients (β=–0.011, p=0.011) and remained significantly associated with eGFR change in a subgroup analysis of the eGFR < 90 group (β=–0.015, p=0.035). baPWV was independently associated with cardiovascular events (odds ratio=1.002, p=0.048) in the eGFR < 90 group, but not in the eGFR ≥ 90 group. The receiver operative characteristic curve analysis showed that 1,568 cm/sec was the cut-off value of baPWV for predicting CV events in the eGFR < 90 group (area under curve=0.691, p=0.03) Conclusions: In patients with early stages of CKD, baPWV was independently associated with the decline in renal function and short-term cardiovascular events.
- Subjects :
- Adult
Male
medicine.medical_specialty
Renal function
Subgroup analysis
Pulse Wave Analysis
pulse wave velocity
cardiovascular disease
Internal medicine
medicine
Ankle pulse
Humans
Ankle Brachial Index
Renal Insufficiency, Chronic
Pulse wave velocity
business.industry
Wave velocity
General Medicine
Odds ratio
Middle Aged
medicine.disease
Endocrinology
arterial stiffness
Arterial stiffness
Cardiology
Female
business
chronic kidney disease
Kidney disease
Glomerular Filtration Rate
Research Paper
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 10
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International journal of medical sciences
- Accession number :
- edsair.doi.dedup.....6dad55c1c315bca6382d8d6e3ea3afa0