Back to Search
Start Over
Spectrum of viral infections in patients with cystic fibrosis
- Source :
- European Journal of Microbiology and Immunology. 2:161-175
- Publication Year :
- 2012
- Publisher :
- Akademiai Kiado Zrt., 2012.
-
Abstract
- This review explores the extensive influence of viral infections leading to chronic deterioration of lung function in patients with cystic fibrosis (CF). The mechanisms how viral agents affect the pathogenesis as well as the inflammatory and immune response of CF are discussed. Viral infections of the upper and lower respiratory tract due to viruses in CF patients and methods for diagnosis of respiratory viruses are described in detail. The importance of respiratory and non-respiratory viral agents for the pathogenesis, especially for the exacerbation of bacterial lower respiratory tract infections and course of CF, is stressed, especially emphasizing respiratory syncytial virus, influenza virus, rhinovirus, and human herpes viruses. Possible harmful effects of further viruses like adenovirus, bocavirus, coronavirus, metapneumovirus, parainfluenzavirus on the lung function of CF patients are discussed. The potential use of adenovirus-based vectors for somatic gene therapy is mentioned.
- Subjects :
- 0303 health sciences
Respiratory tract infections
030306 microbiology
business.industry
viruses
Genetic enhancement
Review Article
medicine.disease_cause
medicine.disease
Cystic fibrosis
Virology
Virus
3. Good health
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Immune system
Immunology
Medicine
030212 general & internal medicine
Rhinovirus
business
Coronavirus
Respiratory tract
Subjects
Details
- ISSN :
- 20628633 and 2062509X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- European Journal of Microbiology and Immunology
- Accession number :
- edsair.doi.dedup.....6daa59879bb48cef06c8e286286ec0ec