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Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 291:R518-R529
- Publication Year :
- 2006
- Publisher :
- American Physiological Society, 2006.
-
Abstract
- Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of temperature-sensitive and insensitive neurons. Immunohistochemical procedures identified the extent of various ionic channels in rat PO/AH neurons. These included pacemaker current channels [i.e., hyperpolarization-activated cyclic nucleotide-gated channels (HCN)], background potassium leak channels (TASK-1 and TRAAK), and transient receptor potential channel (TRP) TRPV4. PO/AH neurons showed dense TASK-1 and HCN-2 immunoreactivity and moderate TRAAK and HCN-4 immunoreactivity. In contrast, the neuronal cell bodies did not label for TRPV4, but instead, punctate labeling was observed in traversing axons or their terminal endings. On the basis of these results and previous electrophysiological studies, Hodgkin–Huxley-like models were constructed. These models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons.
- Subjects :
- Male
Physiology
Population
Hypothalamus
Action Potentials
Models, Biological
Ion Channels
Body Temperature
Rats, Sprague-Dawley
Physiology (medical)
Animals
education
Ionic Channels
Neurons
Regulation of gene expression
education.field_of_study
Chemistry
Extramural
Electric Conductivity
Conductance
Rats
Sprague dawley
Preoptic area
Gene Expression Regulation
nervous system
Neuroscience
Anterior hypothalamus
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 291
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....6da9f3be0064c951782eb86301f00ef4
- Full Text :
- https://doi.org/10.1152/ajpregu.00039.2006