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18F-Fluorodeoxyglucose-positron Emission Tomography/Computed Tomography Imaging of Metastatic Nasopharyngeal Cancer with Emphasis on the Distribution of Bone Metastases
- Source :
- World Journal of Nuclear Medicine, World Journal of Nuclear Medicine, Vol 16, Iss 3, Pp 192-196 (2017)
- Publication Year :
- 2017
- Publisher :
- Medknow Publications & Media Pvt Ltd, 2017.
-
Abstract
- Distant metastases change the prognosis of patients with nasopharyngeal carcinoma (NPC) which most commonly metastasizes to the bone. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is reported as useful in imaging NPC metastases. Our study assesses the incidence and distribution of bone metastases detected by 18F-FDG PET/CT in NPC. 717 18F-FDG PET/CT scan reports of histologically proven NPC patients imaged in Singapore General Hospital, Singapore, between 2003 and 2009 were reviewed for the total number of metastases (scanned from vertex to mid-thigh) and analyzed for distribution. Of the 709 FDG avid metastases in these reports, 357/709 (50.35%) were locoregional nodal metastasis and 352/709 (49.65%) were distant metastases of which 192/709 (27.08%) of total metastases and 54.54% of distant metastases (192/352) were in the bones. The majority of the bone lesions 125/192 (65.1%) were in the axial skeleton with 109/192 (56.77%) in the lower skeleton (thoracolumbar spine, sacrum, and pelvis). The incidence of bone metastases in our study (27.08%) was higher than that reported in other studies, for example, 15% by Liu et al. and 11% (230 patients) by Caglar et al. Bone metastases have been reported in the femurs and the feet and as such some metastases may have been outside the field of view of the scans. In our study, 27% of FDG avid NPC metastases are in the bones.
- Subjects :
- lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty
Axial skeleton
lcsh:R895-920
Computed tomography
positron emission tomography/computed tomography
030218 nuclear medicine & medical imaging
Fluorodeoxyglucose positron emission tomography
03 medical and health sciences
0302 clinical medicine
medicine
Pelvis
Nasopharyngeal cancer
medicine.diagnostic_test
business.industry
Bone metastases
nasopharyngeal carcinoma
medicine.disease
Sacrum
medicine.anatomical_structure
Nasopharyngeal carcinoma
Positron emission tomography
030220 oncology & carcinogenesis
Original Article
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 16073312 and 14501147
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- World Journal of Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....6da162d7d2396dc75d7fcc6c8216e726