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Enteroviruses and coronaviruses: similarities and therapeutic targets
- Source :
- Expert Opinion on Therapeutic Targets, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Introduction: Enteroviruses are common viruses causing a huge number of acute and chronic infections and producing towering economic costs. Similarly, coronaviruses cause seasonal mild infections, epidemics, and even pandemics and can lead to severe respiratory symptoms. It is important to develop broadly acting antiviral molecules to efficiently tackle the infections caused by thes. Areas covered: This review illuminates the differences and similarities between enteroviruses and coronaviruses and examines the most appealing therapeutic targets to combat both virus groups. Publications of both virus groups and deposited structures discovered through PubMed to March 2021 for viral proteases have been evaluated. Expert opinion: The main protease of coronaviruses and enteroviruses share similarities in their structure and function. These proteases process their viral polyproteins and thus drugs that bind to the active site have potential to target both virus groups. It is important to develop drugs that target more evolutionarily conserved processes and proteins. Moreover, it is a wise strategy to concentrate on processes that are similar between several virus families.
- Subjects :
- Proteases
Polyproteins
viruses
medicine.medical_treatment
Clinical Biochemistry
coronavirus
Review
SARS-COV-2
Biology
medicine.disease_cause
Antiviral Agents
3C protease
Virus
Substrate Specificity
03 medical and health sciences
Drug Discovery
Pandemic
medicine
Animals
Humans
Virus classification
Enterovirus
030304 developmental biology
Coronavirus
Pharmacology
0303 health sciences
Protease
030306 microbiology
COVID-19
Virology
3. Good health
Cysteine Endopeptidases
main protease
Molecular Medicine
Research Article
Subjects
Details
- ISSN :
- 17447631 and 14728222
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Therapeutic Targets
- Accession number :
- edsair.doi.dedup.....6d8f9120bc28eeb5b7c9baeee59ebd1d