Response to Comment on Redondo et al. Racial/Ethnic Minority Youth With Recent-Onset Type 1 Diabetes Have Poor Prognostic Factors. Diabetes Care 2018;41:1017–1024

We thank Dr. Nwosu for his thoughtful comments (1). We agree that insulin resistance influences insulin dose–adjusted hemoglobin A1c (IDAA1c). Nagl et al. (2) observed that the partial remission period was less frequent and shorter in girls than boys, but, without C-peptide measurements, the authors could only speculate that higher insulin resistance or lower insulin secretion might explain their findings. However, we found that, adjusting for BMI, age, and sex, insulin doses were still different between African Americans (AAs) and non-Hispanic whites (NHWs) ( P < 0.001) (3), suggesting that after controlling for factors that increase insulin resistance there was still a difference in insulin dose, and thus in IDAA1c. Other measures of partial remission period, e.g., insulin dose, are also affected by insulin resistance. Furthermore, although defining partial remission period based on …