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Gestational jet lag predisposes to later-life skeletal and cardiac disease
- Source :
- Chronobiology International, 36(5), 657-671. Informa Healthcare
- Publication Year :
- 2019
- Publisher :
- Informa Healthcare, 2019.
-
Abstract
- Circadian rhythm disturbance (CRD) increases the risk of disease, e.g. metabolic syndrome, cardiovascular disease, and cancer. In the present study, we investigated later life adverse health effects triggered by repeated jet lag during gestation. Pregnant mice were subjected to a regular light-dark cycle (CTRL) or to a repeated delay (DEL) or advance (ADV) jet lag protocol. Both DEL and ADV offspring showed reduced weight gain. ADV offspring had an increased circadian period, and an altered response to a jet lag was observed in both DEL and ADV offspring. Analysis of the bones of adult male ADV offspring revealed reduced cortical bone mass and strength. Strikingly, analysis of the heart identified structural abnormalities and impaired heart function. Finally, DNA methylation analysis revealed hypermethylation of miR17-92 cluster and differential methylation within circadian clock genes, which correlated with altered gene expression. We show that developmental CRD affects the circadian system and predisposes to non-communicable disease in adult life.
- Subjects :
- medicine.medical_specialty
Genotype
Heart Diseases
Physiology
Offspring
Period (gene)
Photoperiod
Circadian clock
030209 endocrinology & metabolism
03 medical and health sciences
0302 clinical medicine
Pregnancy
Sleep Disorders, Circadian Rhythm
Physiology (medical)
Internal medicine
Circadian Clocks
medicine
Animals
Circadian rhythm
Jet Lag Syndrome
business.industry
medicine.disease
Circadian Rhythm
Mice, Inbred C57BL
Disease Models, Animal
Endocrinology
DNA methylation
Gestation
Female
medicine.symptom
Metabolic syndrome
Bone Diseases
business
Weight gain
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15256073 and 07420528
- Volume :
- 36
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Chronobiology International
- Accession number :
- edsair.doi.dedup.....6d83ce5e39205df1eed2bd0bd29abade