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Long-Term Use of Ticagrelor in Patients with Coronary Artery Disease
- Source :
- Current Cardiology Reports. 19
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Purpose of Review: This review aims to summarize and discuss safety and effectiveness of the long-term use of ticagrelor in patients with coronary artery disease (CAD). Recent Findings: Ticagrelor is an orally administered, direct, and reversible inhibitor of the P2Y12-platelet receptor. Long-term use of ticagrelor in patients with previous myocardial infarction (MI) has been investigated in the PEGASUS-TIMI-54 trial. Overall, 21,162 patients with a spontaneous MI 1 to 3 years before randomization were randomly assigned to ticagrelor 90 mg bid, ticagrelor 60 mg bid, or placebo. Compared with placebo, both doses of ticagrelor showed that they were capable of significantly reducing the primary efficacy endpoint, although with a significant increase in TIMI major bleeding. Intracranial hemorrhage or fatal bleeding did not differ across groups. Summary: These findings establish clear benefit of DAPT extension with ticagrelor beyond 1 year of treatment, which comes with a tradeoff of clinically meaningful bleeding. Altogether, current evidence suggests that the duration of DAPT remains a patient-by-patient decision based on thrombotic and bleeding risk profiles.
- Subjects :
- Blood Platelets
Ticagrelor
medicine.medical_specialty
Adenosine
Myocardial Infarction
Hemorrhage
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Internal medicine
Bleeding event
Humans
Medicine
Platelet
In patient
030212 general & internal medicine
Myocardial infarction
Purinergic P2Y Receptor Antagonists
Ischemic event
Randomized Controlled Trials as Topic
business.industry
Antiplatelet therapy
Thrombosis
P2Y
Purinergic P2Y Receptor Antagonist
medicine.disease
inhibitor
Treatment Outcome
Thrombosi
Cardiology
Blood Platelet
Cardiology and Cardiovascular Medicine
business
Human
medicine.drug
Subjects
Details
- ISSN :
- 15343170 and 15233782
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Cardiology Reports
- Accession number :
- edsair.doi.dedup.....6d6d15892be26ed54e5c940d4133e2bb