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Secondary Leprosy Infection in a Patient With Psoriasis During Treatment With Infliximab
- Source :
- JCR: Journal of Clinical Rheumatology. 17:269-271
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- Tumor necrosis factor α antagonists are proven to be effective for the treatment of chronic inflammatory conditions, such as psoriasis. A major concern for patients is the risk of acquiring granulomatous infectious diseases caused by the immunosuppressive effects of the drugs. We report a 60-year-old man with psoriasis who underwent infliximab treatment for 2 years and developed secondary leprosy, presenting extensive erythematous and infiltrated plaques on the trunk and limbs with loss of sensitivity (thermal, pain and tactile). The skin lesion biopsy showed perivascular epithelioid granulomas, nodular dermal aggregates of foamy macrophages and bundles of acid-fast bacilli. The clinical picture associated with histopathologic evaluation suggested borderline lepromatous leprosy. Before infliximab treatment, the patient had a positive tuberculin skin test and underwent chemoprophylaxis treatment for latent tuberculosis. Although the tuberculin reactivity suggests a strong correlation with a latent Mycobacterium tuberculosis infection, the possibility of infections by other mycobacteria, such as Mycobacterium leprae, should not be discarded.
- Subjects :
- Male
medicine.medical_specialty
Antitubercular Agents
Tuberculin
Leprostatic Agents
Opportunistic Infections
Mycobacterium tuberculosis
Rheumatology
Latent Tuberculosis
Psoriasis
medicine
Humans
Leprosy, Borderline
Mycobacterium leprae
biology
Latent tuberculosis
Tumor Necrosis Factor-alpha
business.industry
Borderline lepromatous leprosy
Antibodies, Monoclonal
Middle Aged
biology.organism_classification
medicine.disease
Dermatology
Infliximab
Leprosy
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 10761608
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- JCR: Journal of Clinical Rheumatology
- Accession number :
- edsair.doi.dedup.....6d66ee0cf49683c779d61d0392cbeb44