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[Determination of Antifungal Drugs in Fish and Livestock Products Using LC-MS/MS]
- Source :
- Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 60(3)
- Publication Year :
- 2019
-
Abstract
- We developed an analytical method for determining 15 antifungal drugs, 2 antiparasitic drugs, and 3 veterinary drugs in fish and livestock products using LC-MS/MS. First, 50% ethanol was added to their products, and the mixture was homogenized to reduce drug degradation. Thereafter, 20 drugs were extracted from the pretreated sample mixture using acetonitrile. Cleanup was performed using an alumina-N SPE cartridge. Finally, chromatographic separation was performed using a fully porous octadecyl silanized silica column. The new method is applicable to fish in which the matrix hampers accurate analysis. It was validated on 8 fish and livestock products. Drug recovery rates ranged from 70.2 to 109.3%, RSDs of repeatability were
- Subjects :
- Drug
Reproducibility
Chromatography
Veterinary Drugs
Antifungal Agents
Meat
business.industry
Chemistry
Antifungal drugs
media_common.quotation_subject
Reproducibility of Results
Food Contamination
General Medicine
Repeatability
Matrix (chemical analysis)
Cartridge
Seafood
Tandem Mass Spectrometry
Animals
Livestock
business
media_common
Chromatography, Liquid
Subjects
Details
- ISSN :
- 00156426
- Volume :
- 60
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
- Accession number :
- edsair.doi.dedup.....6d4bd41e840d451c56f5b68f996766f6