Back to Search
Start Over
Maternal Body Mass Index and Risk of Congenital Heart Defects in Infants: A Dose-Response Meta-Analysis
- Source :
- BioMed Research International, BioMed Research International, Vol 2019 (2019)
- Publication Year :
- 2019
- Publisher :
- Hindawi, 2019.
-
Abstract
- Objective. The exact shape of the dose-response relationship between maternal body mass index (BMI) and the risk of congenital heart defects (CHDs) in infants has not been clearly defined yet. This study aims to further clarify the relationship between maternal obesity and the risk of CHDs in infants by an overall and dose-response meta-analysis. Methods. PubMed, Embase, and Web of Science databases were searched to identify all related studies. The studies were limited to human cohort or case-control studies in English language. Random-effect models and dose-response meta-analysis were used to synthesize the results. Heterogeneity, subgroup analysis, sensitivity analysis, and publication bias were also assessed. Results. Nineteen studies with 2,416,546 participants were included in our meta-analysis. Compared with the mothers with normal weight, the pooled relative risks (RRs) of infants with CHDs were 1.08 (95% CI=1.03-1.13) in overweight and 1.23 (95% CI=1.17-1.29) in obese mothers. According to the findings from the linear meta-analysis, we observed an increased risk of infants with CHDs (RR=1.07, 95% CI=1.06-1.08) for each 5 kg/m2 increase in maternal BMI. A nonlinear relationship between maternal BMI and risk of infants with CHDs was also found (p=0.012). Conclusion. The results from our meta-analysis indicate that increased maternal BMI is related to increased risk of CHDs in infants.
- Subjects :
- Heart Defects, Congenital
medicine.medical_specialty
lcsh:Medicine
Subgroup analysis
Review Article
030204 cardiovascular system & hematology
Overweight
General Biochemistry, Genetics and Molecular Biology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
Medicine
Humans
Mass index
030212 general & internal medicine
Obesity
General Immunology and Microbiology
business.industry
Obstetrics
lcsh:R
Infant, Newborn
Infant
General Medicine
Publication bias
Pregnancy Complications
Relative risk
Meta-analysis
Cohort
Female
medicine.symptom
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....6d480b83e04ba3efa45b20d9857646fa